The Great Lifespan Escape

At the time when the lines begin, in the mid-18th century, life expectancy in Europe and the Americas was around 35, where it had been parked for the 225 previous years for which we have data.3 Life expectancy for the world as a whole was 29. These numbers are in the range of expected life spans for most of human history. The life expectancy of hunter-gatherers is around 32.5, and it probably decreased among the peoples who first took up farming because of their starchy diet and the diseases ...

 American Exceptionalism Prevents Americans from Recognizi...

Americans enjoy lower qualities of life on every single indicator that you can possibly think of. Life expectancy in France and Spain is 83 years, but in America it’s only 78 years?—?that’s half a decade of life, folks. The same is true for things like maternal mortality, stress, work and leisure, press freedom, quality of democracy?—?every single thing you can think of that impacts how well, happily, meaningfully, and sanely you live is worse in America, by a very long way. These are forms o...

 Physical and Actuarial Escape Velocities

The escape velocity cusp is closer than you might guess. Since we are already so long lived, even a 30% increase in healthy life span will give the first beneficiaries of rejuvenation therapies another 20 years—an eternity in science—to benefit from second-generation therapies that would give another 30%, and so on ad infinitum. Thus, if first-generation rejuvenation therapies were universally available and this progress in developing rejuvenation therapy could be indefinitely maintained, the...

 Caloric Restriction Could Mean a 20% Extension in Lifespan

Sinclair and several other prominent gerontologists are presently seeking human therapies based on the long-standing observation that lifelong restriction of caloric intake considerably extends both the healthy and total life span of nearly all species in which it has been tried, including rodents and dogs. Drugs that elicit the gene expression changes that result from caloric restriction might, these workers assert, extend human life span by something approaching the same proportion as seen ...

 Science is the "Crucible" for Extending Life

People are living longer and societies are getting grayer. You hear about it all the time. You read about it in your newspapers. You hear about it on your television sets. Sometimes I'm concerned that we hear about it so much that we've come to accept longer lives with a kind of a complacency, even ease. But make no mistake, longer lives can and, I believe, will improve quality of life at all ages. Now to put this in perspective, let me just zoom out for a minute. More years were added to av...

 Okinawa Culture as a Blue Zone

We found our second Blue Zone on the other side of the planet, about 800 miles south of Tokyo, on the archipelago of Okinawa. Okinawa is actually 161 small islands. And in the northern part of the main island, this is ground zero for world longevity. This is a place where the oldest living female population is found. It's a place where people have the longest disability-free life expectancy in the world. They have what we want. They live a long time, and tend to die in their sleep, very quick...